Docetaxel (200 mg)
docetaxel trihydrate
CAS: 148408-66-6
Molecular Formula: C43H55NO15
Docetaxel (200 mg) - Names and Identifiers
| Name | docetaxel trihydrate |
| Synonyms | Docetaxel (200 mg) Taxotere Trihydrate Docetaxel·Trihydrate docetaxel trihydrate Docetaxel(trihydrous) RP56976 (NSC 628503) Trihydrate (2AR,4S,4aS,6R,9S,11S,12S,12aS,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2- (αR,βS)-β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-benzenepropanoic acid, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11- |
| CAS | 148408-66-6 |
| EINECS | 642-361-2 |
| InChI | InChI=1/C43H53NO14.3H2O/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45;;;/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52);3*1H2/t26-,27-,28+,30-,31+,32?,33-,35-,41+,42-,43+;;;/m0.../s1 |
| InChIKey | XCDIRYDKECHIPE-KHDBCEGQSA-N |
Docetaxel (200 mg) - Physico-chemical Properties
| Molecular Formula | C43H55NO15 |
| Molar Mass | 825.91 |
| Melting Point | 186-192°C |
| Boling Point | 1016.9°C at 760 mmHg |
| Flash Point | 568.8°C |
| Solubility | Practically insoluble in water, freely soluble in anhydrous ethanol, soluble in methylene chloride. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White crystalline powder |
| Color | White to OFf-White |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | Melting point 186-192°C |
| In vitro study | Docetaxel is a cytotoxic agent, especially for proliferating cells, which, together with its promotion of microtubule bundle formation and induction of sustained mitotic arrest, the ability to subsequently cause mitotic arrest apoptosis or permanent mitotic arrest is correlated. Docetaxel inhibits microtubule dynamical instability as well as microtubule treadmill, resulting in the inability of chromosomes to segregate into the progeny, which in turn causes premature exit from mitosis rather than arrest at the cell cycle stage. Docetaxel inhibits clonal survival of human cancer cells Hs746T (stomach),AGS (stomach),HeLa (cervix),CaSki (cervix),BxPC3 (pancreas),Capan-1 (pancreas), the IC50 values were 1 nM,1 nM,0.3 nM,0.3 nM,0.3 nM and 0.3 nM, respectively. Docetaxels inhibit endothelial cell migration without affecting microtubule gross morphology or inhibiting cell proliferation, although they can have more subtle effects on microtubule dynamics. Docetaxel inhibits HUVEC migration with an observed IC50 of 1 pM. The HUVEC chemotaxis stimulated by two angiogenic factors, Thymidine phosphorylase or VEGF, was inhibited by Docetaxel with an IC 50 of 10 pM and abolished at 1 nM. Docetaxel induces expression of human monocytes without affecting expression of prostaglandin H synthase-2m (PGHS-2) in macrophages from RAW 264.7 mice. |
| In vivo study | Docetaxel (33 mg/kg/dose, I. v., 3 injections every 4 days) caused a 19.3-day growth delay in M2OL2 colon cancer xenografts. Docetaxel also showed good antitumor activity in MX-1,SK-MEL-2,LX-1 and OVCAR-3 xenografts. Docetaxel was injected twice a week for 14 days to inhibit the angiogenic response of fibroblast growth factor 2 with an IC 50 of 5.4 mg/kg, and when 10 mg/kg Docetaxel was given, completely blocked angiogenesis in mice. Docetaxel is selective for endothelial cell migration and/or microvascularization because infiltration of inflammatory cells into Matrigel plugs is less sensitive to Docetaxel inhibition. |
Docetaxel (200 mg) - Risk and Safety
| WGK Germany | 3 |
| HS Code | 2932996560 |
Supplier List
Product Name: Docetaxel Trihydrate Request for quotation
CAS: 148408-66-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 148408-66-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Docetaxel Trihydrate Visit Supplier Webpage Request for quotationCAS: 148408-66-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: docetaxel trihydrate Request for quotation
CAS: 148408-66-6
Tel: 021-57687675-818
Email: rice@biocompounds.com
Mobile: 13817188755
QQ: 93115722
Send QQ message
CAS: 148408-66-6
Tel: 021-57687675-818
Email: rice@biocompounds.com
Mobile: 13817188755
QQ: 93115722
Product Name: Docetaxel Trihydrate Request for quotation
CAS: 148408-66-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 148408-66-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Docetaxel Trihydrate Visit Supplier Webpage Request for quotationCAS: 148408-66-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: docetaxel trihydrate Request for quotation
CAS: 148408-66-6
Tel: 021-57687675-818
Email: rice@biocompounds.com
Mobile: 13817188755
QQ: 93115722Send QQ message
CAS: 148408-66-6
Tel: 021-57687675-818
Email: rice@biocompounds.com
Mobile: 13817188755
QQ: 93115722
View History